Pyo is a Python module written in C to help DSP script creation. Pyo contains classes for a wide variety of audio signal processing. With pyo, the user will be able to include signal processing chains directly in Python scripts or projects, and to manipulate them in real time through the interpreter. Tools in the pyo module offer primitives, like mathematical operations on audio signals, basic signal processing (filters, delays, synthesis generators, etc.), but also complex algorithms to create sound granulation and other creative audio manipulations. pyo supports the OSC protocol (Open Sound Control) to ease communications between softwares, and the MIDI protocol for generating sound events and controlling process parameters. pyo allows the creation of sophisticated signal processing chains with all the benefits of a mature and widely used general programming language.